Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease

被引：290

作者：

Cheng, K-H ^{[2
]}

Chu, C-S ^{[1
,3
]}

Lee, K-T ^{[1
,3
]}

Lin, T-H ^{[1
,3
]}

Hsieh, C-C ^{[4
]}

Chiu, C-C ^{[3
]}

Voon, W-C ^{[1
,3
]}

Sheu, S-H ^{[1
,3
]}

Lai, W-T ^{[1
,3
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 80708, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Cardiol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Surg, Div Cardiovasc Surg, Kaohsiung, Taiwan

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2008年 / 32卷 / 02期

关键词：

adipocytokines; inflammatory markers; adipose tissues; coronary artery disease; atherosclerosis;

D O I：

10.1038/sj.ijo.0803726

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Epicardial and abdominal adipose tissues have recently been demonstrated to play inflammatory roles in coronary atherosclerosis. We sought to compare tissue adipocytokine levels of these two anatomically distinct adipose stores in patients with and without coronary artery diseases (CAD). Design: Samples of abdominal and epicardial fat tissues were harvested to detect the levels of adipocytokines and pro-inflammatory mediators. Subjects: Forty-six patients with CAD who underwent coronary artery bypass surgery and 12 non-CAD control subjects who underwent other types of open-heart surgery. Measurements: Tissue levels of adipocytokines (adiponectin, leptin and visfatin) and proinflammatory mediators (tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)) were determined by enzyme-linked immunosorbent assay. Results: Tissue levels of TNF-alpha, IL-6, leptin and visfatin were significantly higher in CAD patients relative to control subjects. In addition, significantly higher tissue levels of these four cytokines from abdominal fat depots were found compared to those from epicardial fat in CAD patients. Conversely, in comparison with control subjects, tissue levels of adiponectin were significantly reduced in CAD patients with a significantly lower tissue levels of abdominal than epicardial fat depots demonstrated. Conclusion: Abdominal adiposity may play more significant role than epicardial fat in the pathogenesis of coronary atherosclerosis.

引用

页码：268 / 274

页数：7

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