A role for Cajal bodies in assembly of the nuclear transcription machinery

被引：55

作者：

Gall, JG ^{[1
]}

机构：

[1] Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA

来源：

FEBS LETTERS | 2001年 / 498卷 / 2-3期

关键词：

Cajal body; nucleus; oocyte; RNA polymerase; transcription;

D O I：

10.1016/S0014-5793(01)02461-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cajal bodies (CBs) are small nuclear organelles that contain the three eukaryotic RNA polymerases and a variety of factors involved in transcription and processing of all types of RNA. A number of these factors, as well as subunits of polymerase (pol) II itself, are rapidly and specifically targeted to CBs when injected into the cell. It is suggested that pol I, pol II, and pol III transcription and processing complexes are preassembled in the CBs before transport to the sites of transcription on the chromosomes and in the nucleoli, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B,V, All rights reserved.

引用

页码：164 / 167

页数：4

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