Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics

被引：88

作者：

Ala-Korpela, Mika ^{[1
]}

机构：

[1] Aalto Univ, Lab Computat Engn Syst Biol & Bioinformat Technol, Espoo 02015, Hut, Finland

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2008年 / 46卷 / 01期

基金：

芬兰科学院;

关键词：

blood plasma and serum; coronary heart disease; data analysis; diagnostics; lipoprotein subclass; metabolomics; metabonomics; nuclear magnetic resonance spectroscopy; quantification; risk assessment;

D O I：

10.1515/CCLM.2008.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

This review focuses on (i) the current status of H-1 NMR spectroscopy to quantify lipoprotein subclasses directly from serum or plasma, and (ii) the applications of H-1 NMR metabonomics of serum in biomedicine. Related to both themes, experimental and data analysis methodologies are discussed together with the biochemical rationales. Particular emphasis is placed on the concepts of risk assessment and diagnostics in relation to the potential clinical role of H-1 NMR metabonomics; recent applications in the area of coronary heart disease and diabetes are addressed in more detail.

引用

页码：27 / 42

页数：16

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