Delineating the mechanism of Alzheimer's disease Aβ peptide neurotoxicity

被引：88

作者：

Cappai, Roberto ^{[1
,2
,3
]}

Barnham, Kevin J. ^{[1
,2
,3
]}

机构：

[1] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Melbourne, Vic 3010, Australia

[3] Mental Hlth Res Inst, Parkville, Vic 3052, Australia

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 03期

关键词：

Alzheimer's disease; amyloid; neurotoxicity; copper; aggregation; reactive oxygen species;

D O I：

10.1007/s11064-007-9469-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Alzheimer's disease neurotoxic amyloid-beta (A beta) peptide is derived from the larger amyloid precursor protein (APP) and is the principal component of the senile plaques in Alzheimer's disease (AD) brains. This mechanism by which A beta mediates neurotoxicity or neuronal dysfunction is not fully resolved. This review will outline some of the key determinants that modulate A beta's activity and the cellular pathways and mechanisms involved.

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页码：526 / 532

页数：7

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