A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses

被引：49

作者：

Hoelscher, Mary A. ^{[1
]}

Singh, Neetu ^{[1
,2
]}

Garg, Sanjay

Jayashankar, Lakshmi ^{[2
]}

Veguilla, Vic ^{[1
]}

Pandey, Aseem ^{[2
]}

Matsuoka, Yumi ^{[1
]}

Katz, Jacqueline M. ^{[1
]}

Donis, Ruben ^{[1
]}

Mittal, Suresh K. ^{[2
]}

Sambhara, Suryaprakash ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA

[2] Purdue Univ, Sch Vet Med, Dept Comparat Pathol, W Lafayette, IN 47907 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 08期

关键词：

D O I：

10.1086/529522

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.

引用

页码：1185 / 1188

页数：4

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