Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease

被引：71

作者：

Bastianetto, S. ^{[1
]}

Krantic, S. ^{[2
]}

Quirion, R. ^{[1
]}

机构：

[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada

[2] INSERM, F-13273 Marseille, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 05期

关键词：

Alzheimer's disease; polyphenols; neuroprotection;

D O I：

10.2174/138955708784223512

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Beta-amyloid (A likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, A associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of A formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.

引用

页码：429 / 435

页数：7

共 55 条

[1] The development of anti-amyloid therapy for Alzheimer's disease - From secretase modulators to polymerisation inhibitors
Aisen, PS
[J]. CNS DRUGS, 2005, 19 (12) : 989 - 996
[2] The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid
Bastianetto, S
Ramassamy, C
Doré, S
Christen, Y
Poirier, J
Quirion, R
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (06) : 1882 - 1890
[3] Neuroprotective effects of green and black teas and their catechin gallate esters against β-amyloid-induced toxicity
Bastianetto, S
Yao, ZX
Papadopoulos, V
Quirion, R
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 23 (01) : 55 - 64
[4] Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands
Caragounis, Aphrodite
Du, Tai
Filiz, Gulay
Laughton, Katrina M.
Volitakis, Irene
Sharples, Robyn A.
Cherny, Robert A.
Masters, Colin L.
Drew, Simon C.
Hill, Andrew F.
Li, Qiao-Xin
Crouch, Peter J.
Barnham, Kevin J.
White, Anthony R.
[J]. BIOCHEMICAL JOURNAL, 2007, 407 : 435 - 450
[5] Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
Cherny, RA
Atwood, CS
Xilinas, ME
Gray, DN
Jones, WD
McLean, CA
Barnham, KJ
Volitakis, I
Fraser, FW
Kim, YS
Huang, XD
Goldstein, LE
Moir, RD
Lim, JT
Beyreuther, K
Zheng, H
Tanzi, RE
Masters, CL
Bush, AI
[J]. NEURON, 2001, 30 (03) : 665 - 676
[6] The green tea polyphenol (-)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons
Choi, YT
Jung, CH
Lee, SR
Bae, JH
Baek, WK
Suh, MH
Park, J
Park, CW
Suh, SI
[J]. LIFE SCIENCES, 2001, 70 (05) : 603 - 614
[7] Intake of flavonoids and risk of dementia
Commenges, D
Scotet, V
Renaud, S
Jacqmin-Gadda, H
Barberger-Gateau, P
Dartigues, JF
[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2000, 16 (04) : 357 - 363
[8] Therapeutic treatments for Alzheimer's disease based on metal bioavailability
Crouch, Peter J.
Barnham, Kevin J.
Bush, Ashley I.
White, Anthony R.
[J]. DRUG NEWS & PERSPECTIVES, 2006, 19 (08) : 469 - 474
[9] γ-secretase modulation with Aβ42-lowering nonsteroidal anti-inflammatory drugs and derived compounds
Czirr, Eva
Weggen, Sascha
[J]. NEURODEGENERATIVE DISEASES, 2006, 3 (4-5) : 298 - 304
[10] Fruit and vegetable juices and Alzheimer's disease:: The Kame Project
Dai, Qi
Borenstein, Amy R.
Wu, Yougui
Jackson, James C.
Larson, Eric B.
[J]. AMERICAN JOURNAL OF MEDICINE, 2006, 119 (09) : 751 - 759

← 1 2 3 4 5 6 →