Nuclear actin dynamics - From form to function

被引：72

作者：

Vartiainen, Maria K. ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biotechnol, Res Program Cellular Biotechnol, Helsinki 00014, Finland

来源：

FEBS LETTERS | 2008年 / 582卷 / 14期

关键词：

actin; nucleus; nuclear transport; actin dynamics; actin-binding protein;

D O I：

10.1016/j.febslet.2008.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Cell biological functions of actin have recently expanded from cytoplasm to nucleus, with actin implicated in such diverse processes as gene expression, transcription factor regulation and intranuclear motility. Actin in the nucleus seems to behave differently than in the cytoplasm, raising new questions regarding the molecular mechanisms by which actin functions in cells. In this review, I will discuss dynamic properties of nuclear actin that are related to its polymerization cycle and nucleocytoplasmic shuttling. By comparing the behaviour of nuclear and cytoplasmic actin and their regulators, I try to dissect the underlying differences of these equally important cellular actin pools. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2033 / 2040

页数：8

共 62 条

[1]

Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators [J].

Archer, SK ;

Claudianos, C ;

Campbell, HD .

BIOESSAYS, 2005, 27 (04) :388-396

[2]

ADF/cofilin and actin dynamics in disease [J].

Bamburg, JR ;

Wiggan, OP .

TRENDS IN CELL BIOLOGY, 2002, 12 (12) :598-605

[3]

Mechanism and biological role of profilin-Srv2/CAP interaction [J].

Bertling, Enni ;

Quintero-Monzon, Omar ;

Mattila, Pieta K. ;

Goode, Bruce L. ;

Lappalainen, Pekka .

JOURNAL OF CELL SCIENCE, 2007, 120 (07) :1225-1234

[4]

A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes [J].

Bohnsack, MT ;

Stüven, T ;

Kuhn, C ;

Cordes, VC ;

Görlich, D .

NATURE CELL BIOLOGY, 2006, 8 (03) :257-263

[5]

Thymosin beta 4 expression and nuclear transport are regulated by hMLH1 [J].

Brieger, Angela ;

Plotz, Guido ;

Zeuzem, Stefan ;

Trojan, Joerg .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 364 (04) :731-736

[6]

Cofilin, actin and their complex observed in vivo using fluorescence resonance energy transfer [J].

Chhabra, D ;

dos Remedios, CG .

BIOPHYSICAL JOURNAL, 2005, 89 (03) :1902-1908

[7]

Long-range directional movement of an interphase chromosome site [J].

Chuang, CH ;

Carpenter, AE ;

Fuchsova, B ;

Johnson, T ;

de Lanerolle, P ;

Belmont, AS .

CURRENT BIOLOGY, 2006, 16 (08) :825-831

[8]

Increased importin-β-dependent nuclear import of the actin modulating protein CapG promotes cell invasion [J].

De Corte, V ;

Van Impe, K ;

Bruyneel, E ;

Boucherie, C ;

Mareel, M ;

Vandekerckhove, J ;

Gettemans, J .

JOURNAL OF CELL SCIENCE, 2004, 117 (22) :5283-5292

[9]

Actin and myosin I in the nucleus: what next? [J].

de Lanerolle, P ;

Johnson, T ;

Hofmann, WA .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (09) :742-746

[10]

Mechanisms underlying intranuclear rod formation [J].

Domazetovska, Ana ;

Ilkovski, Biljana ;

Cooper, Sandra T. ;

Ghoddusi, Majid ;

Hardeman, Edna C. ;

Minamide, Laurie S. ;

Gunning, Peter W. ;

Bamburg, James R. ;

North, Kathryn N. .

BRAIN, 2007, 130 :3275-3284

← 1 2 3 4 5 6 7 →