Ligand binding and affinity modulation of integrins

被引:35
作者
Tozer, EC
Hughes, PE
Loftus, JC
机构
[1] Department of Vascular Biology, Scripps Research Institute, VB2, San Diego, CA 92037
关键词
integrins; ligand binding; affinity modulation;
D O I
10.1139/o96-085
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Integrins are cell adhesion receptors that mediate cell-cell and cell-extracellular matrix interactions. The extracellular domains of these receptors possess binding sites for a diverse range of protein Ligands. Ligand binding is divalent cation dependent and involves well-defined motifs in the ligand. Integrins can dynamically regulate their affinity for ligands (inside-out signaling). This ability to rapidly modulate their affinity state is key to their involvement in such processes as cell migration and platelet aggregation. This review will focus on two aspects of integrin function: first, on the molecular basis of ligand-integrin interactions and, second, on the underlying mechanisms controlling the affinity state of integrins for their ligands.
引用
收藏
页码:785 / 798
页数:14
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