Lack of association of HLA class I genes and TNF α-308 polymorphism in toluene diisocyanate-induced asthma

被引：45

作者：

Beghé, B

Padoan, M

Moss, CT

Barton, SJ

Holloway, JW

Holgate, ST

Howell, WM

Mapp, CE

机构：

[1] Univ Padua, Dept Clin & Expt Med, Sect Resp Dis, Padua, Italy

[2] Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy

[3] Southampton Univ Hosp, Histocompatibil & Immunogenet Lab, Southampton, Hants, England

[4] Univ Southampton, Div Infect Inflammat & Repair, Southampton, Hants, England

[5] Univ Southampton, Div Human Genet, Southampton, Hants, England

[6] Univ Ferrara, Dept Clin & Expt Med, Sect Hyg & Occupat Med, I-44100 Ferrara, Italy

来源：

ALLERGY | 2004年 / 59卷 / 01期

关键词：

genes; isocyanates; occupational asthma; polymorphism; susceptibility;

D O I：

10.1046/j.1398-9995.2003.00352.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility. MEthods: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects. Results: Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects. Conclusions: These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

引用

页码：61 / 64

页数：4

共 10 条

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