The comparative biology of neuromelanin and lipofuscin in the human brain

被引：129

作者：

Double, K. L. ^{[1
]}

Dedov, V. N. ^{[1
]}

Fedorow, H. ^{[2
]}

Kettle, E. ^{[1
]}

Halliday, G. M. ^{[1
]}

Garner, B. ^{[1
]}

Brunk, U. T. ^{[3
]}

机构：

[1] Prince Wales Med Res Inst, Randwick, NSW 2031, Australia

[2] Univ Sydney, Discipline Pharmacol, Sydney, NSW 2006, Australia

[3] Linkoping Univ, Dept Pharmacol, SE-58185 Linkoping, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 11期

关键词：

neuromelanin; lipofuscin; human; brain; structure; function; aging; Parkinson's disease;

D O I：

10.1007/s00018-008-7581-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuromelanin and lipofuscin are two pigments produced within the human brain that, until recently, were considered inert cellular waste products of little interest to neuroscience. Recent research has increased our understanding of the nature and interactions of these pigments with their cellular environment and suggests that these pigments may, indeed, influence cellular function. The physical appearance and distribution of the pigments within the human brain differ, but both accumulate in the aging brain and the pigments share some structural features. Lipofuscin accumulation has been implicated in postmitotic cell aging, while neuromelanin is suggested to function as an iron-regulatory molecule with possible protective functions within the cells which produce this pigment. This review presents comparative aspects of the biology of neuromelanin and lipofuscin, as well as a discussion of their hypothesized functions in brain and their possible roles in aging and neurodegenerative disease.

引用

页码：1669 / 1682

页数：14

共 125 条

[1] Up-regulation of the lysosomal system in experimental models of neuronal injury: Implications for Alzheimer's disease [J].

Adamec, E ;

Mohan, PS ;

Cataldo, AM ;

Vonsattel, JP ;

Nixon, RA .

NEUROSCIENCE, 2000, 100 (03) :663-675

[2] EPR investigations of the iron domain in neuromelanin [J].

Aime, S ;

Bergamasco, B ;

Biglino, D ;

Digilio, G ;

Fasano, M ;

Giamello, E ;

Lopiano, L .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1997, 1361 (01) :49-58

[3]

Aime S, 2000, MOVEMENT DISORD, V15, P977, DOI 10.1002/1531-8257(200009)15:5<977::AID-MDS1032>3.0.CO

[4]

2-Q

[5] HISTOCHEMICAL-OBSERVATIONS ON RODENT BRAIN MELANIN [J].

BARDEN, H ;

LEVINE, S .

BRAIN RESEARCH BULLETIN, 1983, 10 (06) :847-851

[6] STUDIES ON NEUROMELANIN .I. A MELANIN SYSTEM IN HUMAN ADULT BRAINSTEM [J].

BAZELON, M ;

FENICHEL, GM ;

RANDALL, J .

NEUROLOGY, 1967, 17 (05) :512-&

[7] Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits [J].

Beach, Thomas G. ;

Sue, Lucia I. ;

Walker, Douglas G. ;

Lue, Lih Fen ;

Connor, Donald J. ;

Caviness, John N. ;

Sabbagh, Marwan N. ;

Adler, Charles H. .

ACTA NEUROPATHOLOGICA, 2007, 114 (04) :419-424

[8] Sequential histochemical studies of neuronal lipofuscin in human cerebral cortex from the first to the ninth decade of life [J].

Benavides, SH ;

Monserrat, AJ ;

Fariña, S ;

Porta, EA .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2002, 34 (03) :219-231

[9] IRON MELANIN INTERACTION AND LIPID-PEROXIDATION - IMPLICATIONS FOR PARKINSONS-DISEASE [J].

BENSHACHAR, D ;

RIEDERER, P ;

YOUDIM, MBH .

JOURNAL OF NEUROCHEMISTRY, 1991, 57 (05) :1609-1614

[10] Brain iron pathways and their relevance to Parkinson's disease [J].

Berg, D ;

Gerlach, M ;

Youdim, MBH ;

Double, KL ;

Zecca, L ;

Riederer, P ;

Becker, G .

JOURNAL OF NEUROCHEMISTRY, 2001, 79 (02) :225-236

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