Targeting IRFs by ubiquitination: regulating antiviral responses

被引：19

作者：

Higgs, Rowan ^{[1
]}

Jefferies, Caroline A. ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, RSCI Res Inst, Dublin 2, Ireland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

antiviral response; cell signalling; interferon regulatory factor (IRF); Toll-like receptor; type I interferon; ubiquitination;

D O I：

10.1042/BST0360453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.

引用

页码：453 / 458

页数：6

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