An 225Ac/213Bi generator system for therapeutic clinical applications:: construction and operation

被引：104

作者：

McDevitt, MR ^{[1
]}

Finn, RD ^{[1
]}

Sgouros, G ^{[1
]}

Ma, DS ^{[1
]}

Scheinberg, DA ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

APPLIED RADIATION AND ISOTOPES | 1999年 / 50卷 / 05期

关键词：

213Bi generator; Bi-213; (225)AC; alpha-particle emitting radionuclide; radioimmunotherapy;

D O I：

10.1016/S0969-8043(98)00151-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method for construction and operation of an Ac-225/Bi-213 generator capable of producing 25-100 mCi of Bi-213 suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described Bi-213 generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：895 / 904

页数：10

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