IL-21 and autoimmune disease - hypothesis and reality?

被引：7

作者：

Holmdahl, Rikard ^{[1
,2
]}

机构：

[1] Karolinska Inst, MBB, S-17177 Stockholm, Sweden

[2] Lund Univ, Lund, Sweden

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 07期

关键词：

autoantibodies; cytokines; rheumatoid arthritis; vaccination;

D O I：

10.1002/eji.200838529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naive T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.

引用

收藏

页码：1800 / 1802

页数：3

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