Morphological development of microglia in the postnatal rat brain - A quantitative study

被引：45

作者：

Orlowski, D ^{[1
]}

Soltys, Z ^{[1
]}

Janeczko, K ^{[1
]}

机构：

[1] Jagiellonian Univ, Inst Zool, Dept Neuroanat, PL-30060 Krakow, Poland

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2003年 / 21卷 / 08期

关键词：

microglia/macrophages; development; quantitative morphology;

D O I：

10.1016/j.ijdevneu.2003.09.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Morphological transformation of lectin-positive microglia/macrophages in the developing rat cerebral hemisphere was analysed using quantitative methods. During the first postnatal month, the cells showed increases in their size and fractal dimension accompanied by a simultaneous decrease in their solidity. Regional variations in dynamics of the process indicated the existence of spatio-temporal developmental gradients within the cerebral hemisphere wall which might correspond with regional patterns of neuronal differentiation. Results of the present study prove that the quantitative methods can be the source of reliable data replacing subjective cell typologies. (C) 2003 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：445 / 450

页数：6

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