Immune response in Wistar rats with high and low level of situational anxiety

被引:2
作者
Loskutova, L. V. [1 ]
Idova, G. V. [1 ]
Gevorgyan, M. M. [1 ]
机构
[1] Russian Acad Med Sci, Siberian Div, Inst Physiol, Novosibirsk, Russia
关键词
neuroimmunomodulation; anxiety; rosette-forming cells; rats;
D O I
10.1007/s10517-007-0411-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 [基础医学];
摘要
A large sample of Wistar rats was divided into 2 groups of high-anxiety and low-anxiety animals by the time spent in the open arms of the elevated plus-maze. This selection was based on the criterion of time (low-anxiety animals, not less than 10 sec; high-anxiety animals, not more than 2 sec). Immunization with T-dependent antigen was performed on the day of behavioral testing. The number of rosette-forming cells in high-anxiety rats significantly decreased on day 5 after immunization. A genetically determined relationship probably exists between low activity of the immune response and high level of reactive anxiety.
引用
收藏
页码:706 / 708
页数:3
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