Dendritic cells: A link between innate and adaptive immunity

被引：191

作者：

Palucka, K ^{[1
]}

Banchereau, J ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75246 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1999年 / 19卷 / 01期

关键词：

dendritic cell; innate immunity; adaptive immunity; tumor immunology; immunotherapy;

D O I：

10.1023/A:1020558317162

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) constitute a unique system of cells able to induce primary immune responses. As a component of the innate immune system, DC organize and transfer information from the outside world to the cells of the adaptive immune system. DC can induce such contrasting states as active immune responsiveness or immunological tolerance. Recent years have brought a wealth of information regarding DC biology and pathophysiology, that shows the complexity of this cell system. Although our understanding of DC biology is still in its infancy, we are now in a position to use DC-based immunotherapy protocols to treat cancer and infectious diseases.

引用

页码：12 / 25

页数：14

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