BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity

被引:135
作者
Bath, Kevin G. [1 ,2 ]
Jing, Deqiang Q.
Dincheva, Iva
Neeb, Christine C.
Pattwell, Siobhan S.
Chao, Moses V. [3 ]
Lee, Francis S. [4 ]
Ninan, Ipe [5 ]
机构
[1] Cornell Univ, Dept Psychiat, Weill Med Coll, Weill Cornell Med Coll, New York, NY 10021 USA
[2] Brown Univ, Dept Neurosci, Providence, RI 02916 USA
[3] NYU, Skirball Inst Biomol Med, Dept Cell Biol Physiol & Neurosci, Helen L & Martin S Kimmel Ctr Biol & Med,Sch Med, New York, NY 10016 USA
[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY USA
[5] NYU, Dept Psychiat, Sch Med, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
BDNF Val66Met SNP; hippocampus; neurogenesis; plasticity; fluoxetine; LTP; NEUROTROPHIC FACTOR BDNF; ACTIVITY-DEPENDENT SECRETION; DENTATE GYRUS; SYNAPTIC PLASTICITY; ANTIDEPRESSANT DRUGS; SIGNALING PATHWAYS; ANIMAL-MODELS; GRANULE CELLS; BRAIN; NEUROGENESIS;
D O I
10.1038/npp.2011.318
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recently, a single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene (BDNF Val66Met) has been linked to the development of multiple forms of neuropsychiatric illness. This SNP, when genetically introduced into mice, recapitulates core phenotypes identified in human BDNF Val66Met carriers. In mice, this SNP also leads to elevated expression of anxiety-like behaviors that are not rescued with the prototypic selective serotonin reuptake inhibitor (SSRI), fluoxetine. A prominent hypothesis is that SSRI-induced augmentation of BDNF protein expression and the beneficial trophic effects of BDNF on neural plasticity are critical components for drug response. Thus, these mice represent a potential model to study the biological mechanism underlying treatment-resistant forms of affective disorders. To test whether the BDNF Val66Met SNP alters SSRI-induced changes in neural plasticity, we used wild-type (BDNF Val/Val) mice, and mice homozygous for the BDNF Val66Met SNP (BDNFMet/Met). We assessed hippocampal BDNF protein levels, survival rates of adult born cells, and synaptic plasticity (long-term potentiation, LTP) in the dentate gyrus either with or without chronic (28-day) fluoxetine treatment. BDNFMet/Met mice had decreased basal BDNF protein levels in the hippocampus that did not significantly increase following fluoxetine treatment. BDNFMet/Met mice had impaired survival of newly born cells and LTP in the dentate gyrus; the LTP effects remained blunted following fluoxetine treatment. The observed effects of the BDNF Val66Met SNP on hippocampal BDNF expression and synaptic plasticity provide a possible mechanistic basis by which this common BDNF SNP may impair efficacy of SSRI drug treatment. Neuropsychopharmacology (2012) 37, 1297-1304; doi:10.1038/npp.2011.318; published online 4 January 2012
引用
收藏
页码:1297 / 1304
页数:8
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