Targeting intercellular signals for bone regeneration from bone marrow mesenchymal progenitors

被引：14

作者：

Long, Fanxin ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, Dept Med, St Louis, MO 63110 USA

来源：

CELL CYCLE | 2008年 / 7卷 / 14期

关键词：

mesenchymal stem cells; osteoblast; osteoclast; osteoporosis; bone regeneration; notch; Wnt; Hh; Bmp; Fgf;

D O I：

10.4161/cc.7.14.6257

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

There are tremendous unmet clinical needs for effective strategies to enhance bone regeneration in vivo. The sustained presence of multipotent mesenchymal progenitors in the bone marrow in aged and osteoporotic individuals offers the potential for therapeutic interventions to induce osteoblast production from the resident progenitors. Recent advances in understanding the intercellular signals governing osteogenic decisions may provide targets for developing novel bone-enhancing therapeutics.

引用

页码：2106 / 2111

页数：6

共 72 条

[1]

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells [J].

Bai, Shuting ;

Kopan, Raphael ;

Zou, Wei ;

Hilton, Matthew J. ;

Ong, Chin-tong ;

Long, Fanxin ;

Ross, F. Patrick ;

Teitelbaum, Steven L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (10) :6509-6518

[2]

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis [J].

Bandyopadhyay, Amitabha ;

Tsuji, Kunikazu ;

Cox, Karen ;

Harfe, Brian D. ;

Rosen, Vicki ;

Tabin, Clifford J. .

PLOS GENETICS, 2006, 2 (12) :2116-2130

[3]

Regulation of osteoblastogenesis and bone mass by Wnt10b [J].

Bennett, CN ;

Longo, KA ;

Wright, WS ;

Suva, LJ ;

Lane, TF ;

Hankenson, KD ;

MacDougald, OA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (09) :3324-3329

[4]

Bone marrow stromal stem cells: Nature, biology, and potential applications [J].

Bianco, P ;

Riminucci, M ;

Gronthos, S ;

Robey, PG .

STEM CELLS, 2001, 19 (03) :180-192

[5]

Mesenchymal stem cells: Revisiting history, concepts, and assays [J].

Bianco, Paolo ;

Robey, Pamela Gehron ;

Simmons, Paul J. .

CELL STEM CELL, 2008, 2 (04) :313-319

[6]

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice [J].

Bodine, PVN ;

Zhao, WG ;

Kharode, YP ;

Bex, FJ ;

Lambert, AJ ;

Goad, MB ;

Gaur, T ;

Stein, GS ;

Lian, JB ;

Komm, BS .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (05) :1222-1237

[7]

High bone density due to a mutation in LDL-receptor-related protein 5 [J].

Boyden, LM ;

Mao, JH ;

Belsky, J ;

Mitzner, L ;

Farhi, A ;

Mitnick, MA ;

Wu, DQ ;

Insogna, K ;

Lifton, RP .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521

[8]

Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis [J].

Chavassieux, PM ;

Arlot, ME ;

Reda, C ;

Wei, L ;

Yates, AJ ;

Meunier, PJ .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (06) :1475-1480

[9]

COHENSOLAL ME, 1991, J BONE MINER RES, V6, P1331

[10]

D'Ippolito, G ;

Schiller, PC ;

Ricordi, C ;

Roos, BA ;

Howard, GA .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (07) :1115-1122

← 1 2 3 4 5 6 7 8 →