Epidural clonidine or bupivacaine as the sole analgesic agent during and after abdominal surgery - A comparative study

被引:27
作者
De Kock, M [1 ]
Gautier, P [1 ]
Pavlopoulou, A [1 ]
Jonniaux, M [1 ]
Lavand'homme, P [1 ]
机构
[1] Univ Louvain, Dept Anesthesiol, St Luc Hosp, B-1200 Brussels, Belgium
关键词
alpha(2)-adrenergic agonist; local anesthetic; pain management;
D O I
10.1097/00000542-199905000-00020
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: The rationale of this study was to compare high-dose epidural clonidine with a more commonly used agent, such as bupivacaine. This was performed to give a more objective idea of the relative analgesic potency of epidural clonidine, Methods: Sixty patients undergoing intestinal surgery during propofol anesthesia were studied. At induction, the patients received epidurally a dose of 10 mg/kg clonidine in 7 ml saline followed by an Infusion of 6 mg.kg(-1).h(-1) (7 ml/h) (group 1, n = 20), a dose of 7 ml bupivacaine, 0.5%, followed by 7 ml/h bupivacaine, 0.25% (group 2, n = 20), or a dose of 7 ml bupivacaine, 0.25%, followed by 7 ml/h bupivacaine, 0.125% (group 3, n = 20), Intraoperatively, increases in arterial blood pressure or heart rate not responding to propofol (0.5 mg/kg) were treated with intravenous alfentanil (0.05 mg/kg), Additional doses of propofol were given to maintain an adequate bispectral index. The epidural infusions were maintained for 12 h. in cases of subjective visual analogue pain scores up to 5 cm at rest or up to 8 cm during coughing, the patients were given access to a patient-controlled analgesia device. Results: During anesthesia, patients in group 1 required less propofol than those in groups 2 and 3 (78 [36-142] mg vs. 229 [184-252] mg and 362 [295-458] mg; P < 0.05) and less alfentanil than patients in group 3 (0 [0-0] mg vs, 11 [6-20] mg; P < 0.05), Analgesia lasted 380 min (range, 180-645 min) in group 1 versus 30 min (range, 25-40 min) in group 2 and 22 min (range, 12.5-42 min) in group 3 (P < 0.05). There was no suggestion of a hemodynamic difference among the three groups except for heart rates that were significantly reduced in patients in group 1, Sedation scores were significantly higher in this group during the first 2 h postoperatively. Conclusion: Our results show that high doses of epidural clonidine potentiate general anesthetics and provide more efficient postoperative analgesia than the two bupivacaine dosage regimens investigated.
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页码:1354 / 1362
页数:9
相关论文
共 18 条
[1]   ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES [J].
ARNSTEN, AFT ;
GOLDMANRAKIC, PS .
SCIENCE, 1985, 230 (4731) :1273-1276
[2]   PHARMACOKINETICS AND DYNAMICS OF INTRAVENOUS, INTRATHECAL, AND EPIDURAL CLONIDINE IN SHEEP [J].
CASTRO, MI ;
EISENACH, JC .
ANESTHESIOLOGY, 1989, 71 (03) :418-425
[3]  
CIACCHERI M, 1983, ACTA CARDIOL, V38, P233
[4]   ANESTHETIC ACTIONS WITHIN THE SPINAL-CORD - CONTRIBUTIONS TO THE STATE OF GENERAL-ANESTHESIA [J].
COLLINS, JG ;
KENDIG, JJ ;
MASON, P .
TRENDS IN NEUROSCIENCES, 1995, 18 (12) :549-553
[5]   A HYPNOTIC RESPONSE TO DEXMEDETOMIDINE, AN ALPHA-2 AGONIST, IS MEDIATED IN THE LOCUS-CERULEUS IN RATS [J].
CORREASALES, C ;
RABIN, BC ;
MAZE, M .
ANESTHESIOLOGY, 1992, 76 (06) :948-952
[6]   Epidural clonidine used as the sole analgesic agent during and after abdominal surgery - A dose-response study [J].
DeKock, M ;
Wiederkher, P ;
Laghmiche, A ;
Scholtes, JL .
ANESTHESIOLOGY, 1997, 86 (02) :285-292
[7]   EPIDURAL CLONIDINE OR SUFENTANIL FOR INTRAOPERATIVE AND POSTOPERATIVE ANALGESIA [J].
DEKOCK, M ;
FAMENNE, F ;
DECKERS, G ;
SCHOLTES, JL .
ANESTHESIA AND ANALGESIA, 1995, 81 (06) :1154-1162
[8]  
DEKOCK M, 1992, ANESTHESIOLOGY, V77, P457
[9]  
DEKOCK M, 1993, ANESTHESIOLOGY, V79, P524
[10]   HEMODYNAMIC AND ANALGESIC ACTIONS OF EPIDURALLY ADMINISTERED CLONIDINE [J].
EISENACH, J ;
DETWEILER, D ;
HOOD, D .
ANESTHESIOLOGY, 1993, 78 (02) :277-287