Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia

被引：374

作者：

Erhardt, S

Blennow, K

Nordin, C

Skogh, E

Lindström, LH

Engberg, G ^{[1
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[2] Sahlgrens Univ Hosp, Dept Clin Neurosci, Unit Neurochem, Molndal, Sweden

[3] Linkoping Univ Hosp, Div Psychiat, Dept Neurosci & Locomot, S-58185 Linkoping, Sweden

[4] Univ Uppsala, Vasteras Cent Hosp, Dept Psychiat Res, Vasteras, Sweden

来源：

NEUROSCIENCE LETTERS | 2001年 / 313卷 / 1-2期

关键词：

schizophrenia; kynurenate; glutamate; cerebrospinal fluid; pathogenesis; N-methyl D-aspartate-receptor;

D O I：

10.1016/S0304-3940(01)02242-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl o-aspartate-receptor. Mounting evidence indicate that the compound is significantly involved in basal neurophysiological processes in the brain. In the present investigation, cerebrospinal fluid (CSF) level of kynurenic acid was analyzed in 28 male schizophrenic patients and 17 male healthy controls by means of high pressure liquid chromatography and fluorescence detection. Schizophrenic patients showed elevated CSF levels of kynurenic acid (1.67 +/- 0.27 nM) compared to the control group (0.97 +/- 0.07 nM). Furthermore, CSF levels of kynurenic acid in schizophrenic patients were also found to correlate with age. The present finding is indicative of a contribution of kynurenic acid in the pathogenesis of schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：96 / 98

页数：3

共 20 条

[1] Increased baseline occupancy of D2 receptors by dopamine in schizophrenia [J].