The long unwinding road of RNA helicases

被引：170

作者：

Bleichert, Franziska

Baserga, Susan J. ^{[1
]}

机构：

[1] Yale Univ, Dept Genet, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[3] Yale Univ, Dept Therapeut Radiol, New Haven, CT 06520 USA

来源：

MOLECULAR CELL | 2007年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.molcel.2007.07.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA helicases comprise a large family of enzymes that are thought to utilize the energy of NTP binding and hydrolysis to remodel RNA or RNA-protein complexes, resulting in RNA duplex strand separation, displacement of proteins from RNA molecules, or both. These functions of RNA helicases are required for all aspects of cellular RNA metabolism, from bacteria to humans. We provide a brief overview of the functions of RNA helicases and highlight some of the recent key advances that have contributed to our current understanding of their biological function and mechanism of action.

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收藏

页码：339 / 352

页数：14

相关论文

共 114 条

[1] Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export [J].

Alcazar-Roman, Abel R. ;

Tran, Elizabeth J. ;

Guo, Shuangli ;

Wente, Susan R. .

NATURE CELL BIOLOGY, 2006, 8 (07) :711-U131

[2] Functions of the exosome in rRNA, snoRNA and snRNA synthesis [J].

Allmang, C ;

Kufel, J ;

Chanfreau, G ;

Mitchell, P ;

Petfalski, E ;

Tollervey, D .

EMBO JOURNAL, 1999, 18 (19) :5399-5410

[3] Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA [J].

Andersen, Christian B. F. ;

Ballut, Lionel ;

Johansen, Jesper S. ;

Chamieh, Hala ;

Nielsen, Klaus H. ;

Oliveira, Cristiano L. P. ;

Pedersen, Jan Skov ;

Seraphin, Bertrand ;

Le Hir, Herve ;

Andersen, Gregers Rom .

SCIENCE, 2006, 313 (5795) :1968-1972

[4] Prp43: An RNA helicase-like factor involved in spliceosome disassembly [J].

Arenas, JE ;

Abelson, JN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :11798-11802

[5] The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity [J].

Ballut, L ;

Marchadier, B ;

Baguet, A ;

Tomasetto, C ;

Séraphin, B ;

Le Hir, H .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (10) :861-869

[6] Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track [J].

Beran, Rudolf K. F. ;

Bruno, Michael M. ;

Bowers, Heath A. ;

Jankowsky, Eckhard ;

Pyle, Anna Marie .

JOURNAL OF MOLECULAR BIOLOGY, 2006, 358 (04) :974-982

[7] Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis [J].

Bernstein, KA ;

Granneman, S ;

Lee, AV ;

Manickam, S ;

Baserga, SJ .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (04) :1195-1208

[8] The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA [J].

Bono, Fulvia ;

Ebert, Judith ;

Lorentzen, Esben ;

Conti, Elena .

CELL, 2006, 126 (04) :713-725

[9] Yeast Ntr1/Spp382 mediates Prp43 function in postspliceosomes [J].

Boon, Kum-Loong ;

Auchynnikava, Tatsiana ;

Edwalds-Gilbert, Gretchen ;

Barrass, J. David ;

Droop, Alastair P. ;

Dez, Christophe ;

Beggs, Jean D. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (16) :6016-6023

[10] Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain [J].

Brenner, TJ ;

Guthrie, C .

RNA, 2006, 12 (05) :862-871

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