Tissue specific distribution of the herpes simplex virus type 1 latency-associated transcripts on polyribosomes during latent infection

被引:7
作者
Goldenberg, D
Mador, N
Panet, A
Steiner, I
机构
[1] Hadassah Univ Hosp, Dept Neurol, Lab Neurovirol, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Virol, IL-91120 Jerusalem, Israel
关键词
HSV-1; latency; LATs; polyribosomes;
D O I
10.3109/13550289809114541
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Transcription of herpes simplex virus type 1 (HSV-1) during latency produces two abundant latency-associated transcripts (LATs). We have recently shown, that during HSV-1 latency in mice trigeminal ganglia (TG) LATs are bound to polyribosomes (J Virol, 1997, 71, 2897-2904). In order to study the possible role of this binding in the latency process, we no rv extend the polyribosomal analysis to brainstem tissues of latently infected mice, that unlike TG do not support viral reactivation. We report here that the relative amounts of the LATs associated with polyribosomes in the brainstems of mice are significantly lower than those present in TG. We therefore show that binding of the 1.5 and 2.0 kilobases LATs to polyribosomes is tissue specific and hypothesize that this association may have a role in the reactivation function of HSV-1.
引用
收藏
页码:426 / 432
页数:7
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