Follicular shuttling of marginal zone B cells facilitates antigen transport

被引：401

作者：

Cinamon, Guy ^{[1
,2
]}

Zachariah, Marcus A. ^{[1
,2
]}

Lam, Olivia M. ^{[1
,2
]}

Foss, Frank W., Jr. ^{[3
]}

Cyster, Jason G. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Virginia, Dept Chem, Charlottesville, VA 22094 USA

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/ni1542

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The splenic marginal zone is a site of blood flow, and the specialized B cell population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown. Here we show that marginal zone B cells were not confined to the marginal zone but continuously shuttled between the marginal zone and follicular areas, such that many of the cells visited a follicle every few hours. Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P(1) and S1P(3). Treatment with an SIP, antagonist caused displacement of marginal zone B cells from the marginal zone. Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells.

引用

页码：54 / 62

页数：9

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