Biphasic decline of CD4 cell count during scheduled treatment interruptions

被引:22
作者
Fagard, C [1 ]
Bandelier, CY
Ananworanich, J
Le Braz, M
Günthard, H
Perneger, T
García, F
Hirschel, B
机构
[1] Univ Hosp, Geneva, Switzerland
[2] HIVNAT, Bangkok, Thailand
[3] Univ Zurich Hosp, Zurich, Switzerland
[4] Hosp Clin Barcelona, Barcelona, Spain
[5] NCHECR, Sydney, NSW, Australia
[6] CHU Vaudois, Lausanne, Switzerland
[7] Kantonsspital St Gallen, St Gallen, Switzerland
[8] Osped Civico, Lugano, Switzerland
[9] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand
[10] Hosp Badalona Germans Trias & Pujol, Badalona, Spain
[11] Hosp Sant Pau, Barcelona, Spain
[12] Hosp Univ Tenerife, Tenerife, Spain
[13] Hosp Parc Tauli, Sabadell, Spain
[14] Khon Kaen Univ, Khon Kaen, Thailand
[15] Bamrasnaradura Inst, Nonthaburi, Thailand
[16] Sanpatong Hosp, Chiang Mai, Thailand
[17] Bangkok Metropolitan Adm, Coll Med, Bangkok, Thailand
[18] Vajira Hosp, Bangkok, Thailand
[19] Buddhachinnaraj Hosp, Phitsanulok, Thailand
[20] Mahidol Univ, Bangkok 10700, Thailand
关键词
D O I
10.1097/01.aids.0000161774.29029.0e
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In 115 patients whose scheduled treatment interruptions (STI) lasted 24 weeks, the CD4 cell count declined by a median of 30 cells/ml/week during the first 4 weeks, compared with 3 cells/ml/week during the next 20 weeks. In multivariate regression, a pronounced early fall in CD4 cells correlated with a higher CD4 cell count at the start of STI, with more gain in CD4 cells during antiretroviral treatment preceding STI, and with a higher viral load at week 4.
引用
收藏
页码:439 / 441
页数:3
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