Blood transfusion usage among adults with sickle cell disease - a single institution experience over ten years

被引：51

作者：

Drasar, Emma ^{[1
,2
]}

Igbineweka, Norris ^{[1
]}

Vasavda, Nisha ^{[1
]}

Free, Matthew ^{[2
]}

Awogbade, Moji ^{[2
]}

Allman, Marlene ^{[2
]}

Mijovic, Aleksandar ^{[2
]}

Thein, Swee Lay ^{[1
,2
]}

机构：

[1] Kings Coll London, Sch Med, James Black Ctr, Div Gene & Cell Based Therapy, London SE5 9NU, England

[2] Kings Coll Hosp London, London, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 152卷 / 06期

基金：

英国医学研究理事会;

关键词：

blood transfusion; sickle cell disease; iron overload; ACUTE CHEST SYNDROME; ANEMIA; HYDROXYUREA; CHILDREN; STROKE; PREVENTION; HEMOGLOBIN;

D O I：

10.1111/j.1365-2141.2010.08451.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

P>Transfusion of red blood cells is a major therapeutic option in sickle cell disease (SCD). There is strong evidence for its efficacy, particularly in primary and secondary stroke prevention in children, however, its use in other areas remains controversial. This study assessed the patterns of transfusion in the adult cohort attending King's College Hospital over a 10-year period, from 2000 to 2009. Total blood usage has increased significantly (P = 0 center dot 006) during this time, with 78% of the blood received by only 6% of the patients. The increase is explained by increased automated red cell exchange and increased usage for planned and acute transfusions for sickle-related complications.

引用

页码：766 / 770

页数：5

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