Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

被引：621

作者：

Bouwmeester, T

Kim, SH

Sasai, Y

Lu, B

DeRobertis, EM

机构：

[1] UNIV CALIF LOS ANGELES,HOWARD HUGHES MED INST,LOS ANGELES,CA 90095

[2] UNIV CALIF LOS ANGELES,DEPT BIOL CHEM,LOS ANGELES,CA 90095

来源：

NATURE | 1996年 / 382卷 / 6592期

关键词：

D O I：

10.1038/382595a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

引用

页码：595 / 601

页数：7

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