Particulate vaccines: on the quest for optimal delivery and immune response

被引：236

作者：

De Temmerman, Marie-Luce ^{[1
]}

Rejman, Joanna ^{[1
]}

Demeester, Jo ^{[1
]}

Irvine, Darrell J. ^{[2
,3
,4
,5
,6
]}

Gander, Bruno ^{[7
]}

De Smedt, Stefaan C. ^{[1
]}

机构：

[1] Univ Ghent, Lab Gen Biochem & Phys Pharm, Fac Pharmaceut Sci, B-9000 Ghent, Belgium

[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[4] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[5] Ragon Inst MGH MIT & Harvard, Boston, MA 02139 USA

[6] Howard Hughes Med Inst, Chevy Chase, MD USA

[7] ETH, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 13-14期

关键词：

HUMAN DENDRITIC CELLS; MHC CLASS-I; ANTIGEN-PRESENTING CELLS; CYTOTOXIC T-LYMPHOCYTES; SURFACE-MODIFIED MICROPARTICLES; EFFICIENT CROSS-PRESENTATION; MONOPHOSPHORYL-LIPID-A; HEPATITIS-B-VACCINE; INFLUENZA VACCINE; POLYELECTROLYTE MICROCAPSULES;

D O I：

10.1016/j.drudis.2011.04.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines.

引用

页码：569 / 582

页数：14

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