Nitroglycosylated meso-arylporphyrins as photoinhibitors of Gram positive bacteria.

被引：23

作者：

Sol, V ^{[1
]}

Branland, P ^{[1
]}

Granet, R ^{[1
]}

Kaldapa, C ^{[1
]}

Verneuil, B ^{[1
]}

Krausz, P ^{[1
]}

机构：

[1] Univ Limoges, Lab Chim Subst Nat, F-87060 Limoges, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(98)00536-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel porphyrins bearing nitro groups and glucosyl moieties vr ere synthesized. The antibacterial activity of these compounds on Escherichia coli and Staphylococcus aureus is described. Results reveal that their photocytotoxicity is markedly dependent on the nature, the number and the linking position of the glycosyl moieties and nitro groups controlling their amphiphilic characters. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3007 / 3010

页数：4

相关论文

共 25 条

[1] HEMATOPORPHYRIN-SENSITIZED PHOTOINACTIVATION OF STREPTOCOCCUS-FAECALIS [J].

BERTOLONI, G ;

SALVATO, B ;

DALLACQUA, M ;

VAZZOLER, M ;

JORI, G .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 39 (06) :811-816

[2] PHOTOSENSITIZERS OF THE PORPHYRIN AND PHTHALOCYANINE SERIES FOR PHOTODYNAMIC THERAPY [J].

BONNETT, R .

CHEMICAL SOCIETY REVIEWS, 1995, 24 (01) :19-33

[3] GLYCOSYLATED CATIONIC PORPHYRINS AS POTENTIAL AGENTS IN CANCER PHOTOTHERAPY [J].

DRIAF, K ;

KRAUSZ, P ;

VERNEUIL, B ;

SPIRO, M ;

BLAIS, JC ;

BOLBACH, G .

TETRAHEDRON LETTERS, 1993, 34 (06) :1027-1030

[4] Synthesis of glycosylated cationic porphyrins as potential agents in photodynamic therapy [J].

Driaf, K ;

Granet, R ;

Krausz, P ;

Kaouadji, M ;

Thomasson, F ;

Chulia, AJ ;

Verneuil, B ;

Spiro, M ;

Blais, JC ;

Bolbach, G .

CANADIAN JOURNAL OF CHEMISTRY, 1996, 74 (08) :1550-1563

[5] FLUORESCENCE SPECTRAL CHANGES OF HEMATOPORPHYRIN DERIVATIVE UPON BINDING TO LIPID VESICLES, STAPHYLOCOCCUS-AUREUS AND ESCHERICHIA-COLI-CELLS [J].

EHRENBERG, B ;

MALIK, Z ;

NITZAN, Y .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1985, 41 (04) :429-435

[6] Synthesis and structural analysis of novel meso-glycosyarylprophyrins for application to oncological phototherapy [J].

Gaud, O ;

Granet, R ;

Kaouadji, M ;

Krausz, P ;

Blais, JC ;

Bolbach, G .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1996, 74 (04) :481-499

[7] ORTHO-(DIFLUOROMETHYL)ARYL-BETA-D-GLUCOSIDES AND PARA-(DIFLUOROMETHYL)ARYL-BETA-D-GLUCOSIDES - A NEW CLASS OF ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF BETA-GLUCOSIDASES [J].

HALAZY, S ;

BERGES, V ;

EHRHARD, A ;

DANZIN, C .

BIOORGANIC CHEMISTRY, 1990, 18 (03) :330-344

[8]

KIEDA C, 1986, INVAS METAST, V6, P347

[9] SYNTHESIS AND CHARACTERIZATION OF NEW STYLE OF WATER-SOLUBLE GLYCOSYLATED PORPHYRINS AS A SPECTROPHOTOMETRIC REAGENT FOR METAL-IONS [J].

KOHATA, K ;

HIGASHIO, H ;

YAMAGUCHI, Y ;

KOKETSU, M ;

ODASHIMA, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1994, 67 (03) :668-679

[10] MEMBRANE-DISORGANIZING PROPERTY OF POLYMYXIN-B NONAPEPTIDE [J].

LAM, C ;

HILDEBRANDT, J ;

SCHUTZE, E ;

WENZEL, AF .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 18 (01) :9-15