RTS, a computer program for the experimental set-up and interpretation of ruggedness tests

被引:14
作者
Questier, F [1 ]
Vander Heyden, Y [1 ]
Massart, DL [1 ]
机构
[1] Free Univ Brussels, Inst Pharmaceut, B-1090 Brussels, Belgium
关键词
ruggedness test strategy; method validation; experimental design; software;
D O I
10.1016/S0731-7085(98)00042-9
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A computer program is described for the experimental set-up and interpretation of ruggedness tests. The implemented strategy was based on a number of case studies and contains both recommended designs and minimal designs. The minimal designs reduce the number of experiments, but they cannot be statistically interpreted based on the interaction or dummy factor effects. The use of randomization tests as an alternative statistical interpretation method for the significance of the effects was examined. Some of the minimal designs are expandable to designs with characteristics similar to those of the recommended designs. The program is designed to facilitate the selection of the designs and the interpretation of the results and to prevent or detect problems such as drifting of responses. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:287 / 303
页数:17
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