Synaptic slaughter in Alzheimer's disease

被引：319

作者：

Coleman, PD

Yao, PJ

机构：

[1] Univ Rochester, Ctr Aging & Dev Biol, Rochester, NY 14642 USA

[2] NIA, Gerontol Res Ctr, NIH, Neurosci Lab, Baltimore, MD 21224 USA

来源：

NEUROBIOLOGY OF AGING | 2003年 / 24卷 / 08期

关键词：

Alzheimer's disease; synapses; neurofibrillary tangles; synaptic vesicle trafficking; gene expression profiling; SENILE DEMENTIA; NEUROFIBRILLARY TANGLES; SYNAPTOPHYSIN MESSAGE; FRONTAL-CORTEX; NEURONS; EXPRESSION; DENSITY;

D O I：

10.1016/j.neurobiolaging.2003.09.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1023 / 1027

页数：5

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