Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

被引：316

作者：

Baba, TW

Liska, V

Khimani, AH

Ray, NB

Dailey, PJ

Penninck, D

Bronson, R

Greene, MF

McClure, HM

Martin, LN

Ruprecht, RM

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Tufts Univ, Sch Med, Dept Pediat, Div Newborn Med, Boston, MA 02111 USA

[4] Chiron Corp, Emeryville, CA 94608 USA

[5] Tufts Univ, Sch Vet Med, Dept Radiol, N Grafton, MA 01536 USA

[6] Tufts Univ, Sch Vet Med, Boston, MA 02111 USA

[7] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Boston, MA 02114 USA

[8] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA

[9] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 02期

关键词：

D O I：

10.1038/5557

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A substantial risk in using live attenuated, multiply deleted viruses as vaccines against AIDS is their potential to induce AIDS. A mutant of the simian immunodeficiency virus (SIV) with large deletions in nef and vpr and in the negative regulatory element induced AIDS in six of eight infant macaques vaccinated orally or intravenously. Early signs of immune dysfunction were seen in the remaining two offspring. Prolonged follow-up of sixteen vaccinated adult macaques also showed resurgence of chronic viremia in four animals: two of these developed early signs of disease and one died of AIDS. We conclude that this multiply deleted SIV is pathogenic and that human AIDS vaccines built on similar prototypes may cause AIDS.

引用

页码：194 / 203

页数：10

共 42 条

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