Mining small-molecule screens to repurpose drugs

被引：66

作者：

Swamidass, S. Joshua ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Lab & Genom Med, St Louis, MO 63130 USA

来源：

BRIEFINGS IN BIOINFORMATICS | 2011年 / 12卷 / 04期

关键词：

Data mining; drug repurposing; high-throughput screening; data analysis; chemical informatics; LARGE-SCALE; IN-SILICO; THROUGHPUT; SIMILARITY; STABILITY; DRUGBANK; BIOLOGY; ENRICHMENT; DISCOVERY; LIBRARIES;

D O I：

10.1093/bib/bbr028

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Repurposing and repositioning drugs-discovering new uses for existing and experimental medicines-is an attractive strategy for rescuing stalled pharmaceutical projects, finding treatments for neglected diseases, and reducing the time, cost and risk of drug development. As this strategy emerged, academic researchers began performing high-throughput screens (HTS) of small molecules-the type of experiments once exclusively conducted in industry-and making the data from these screens available to all. Several methods can mine this data to inform repurposing and repositioning efforts. Despite these methods' limitations, it is hopeful that they will accelerate the discovery of new uses for known drugs, but this hope has not yet been realized.

引用

页码：327 / 335

页数：9

共 59 条

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