T cell responses to Listeria monocytogenes

被引：88

作者：

Lara-Tejero, M ^{[1
]}

Pamer, EG ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dept Med Immunol Program, Infect Dis Serv, New York, NY 10021 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 01期

关键词：

D O I：

10.1016/j.mib.2003.12.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Owing to its unique intracellular biology that allows it to gain access to the host cell cytosol, Listeria monocytogenes induces potent, protective CD8 responses. The study of these responses has served as a paradigm to understand cell-mediated immunity to microbial pathogens. The availability of mutants specifically defective in unique aspects of the intracellular biology of this pathogen has greatly aided these studies. During the past few years, progress has been made to understand the contribution of the innate immune system and CD4 T cells in the generation of robust, long lasting CD8 responses to L. monocytogenes.

引用

页码：45 / 50

页数：6

共 57 条

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