Relative importance of NF-κB p50 in mycobacterial infection

被引：58

作者：

Yamada, H ^{[1
]}

Mizuno, S ^{[1
]}

Reza-Gholizadeh, R ^{[1
]}

Sugawara, I ^{[1
]}

机构：

[1] Res Inst TB, Dept Mol Pathol, Tokyo 2040022, Japan

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 11期

关键词：

D O I：

10.1128/IAI.69.11.7100-7105.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To understand the role of NF-kappaB in the development of murine tuberculosis in vivo, NF-kappaB p50 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne-infection apparatus. These mice developed multifocal necrotic pulmonary lesions or lobar pneumonia. Compared with the levels in wild-type mice, pulmonary inducible nitric oxide synthase, interleukin-2 (IL-2), gamma interferon, and tumor necrosis factor alpha mRNA levels were significantly low but expression of IL-10 and transforming growth factor beta mRNAs were within the normal ranges. The pulmonary IL-6 mRNA expression level was higher. Therefore, NT-kappaB and its interaction with host cells play an important role in the pathogenesis of tuberculosis.

引用

页码：7100 / 7105

页数：6

共 34 条

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