Retinal degeneration under the effect of antibodies to recoverin

被引：7

作者：

Bazhin, AV

Slepova, OS

Tikhomirova, NK

机构：

[1] Moscow MV Lomonosov State Univ, An Belozerskii Inst Physicochem Biol, Moscow, Russia

[2] G Helmholtz Inst Eye Dis, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 04期

关键词：

recoverin; paraneoplastic antigens; retinal degeneration; uveitis;

D O I：

10.1023/A:1017952102887

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Serious changes in the retina, diagnosed as retinal degeneration and uveitis, are observed only in the presence of high titers of antibodies to recoverin (Ca2+-binding protein, a paraneoplastic antigen) in the blood of rabbits. Negligible changes in the retina of rabbits with low antibody titers are detected only by cytohistochemical. analysis of the retina. No changes in the retina develop in rabbits intravenously injected with antibodies to recoverin.

引用

收藏

页码：350 / 352

页数：3

相关论文

共 10 条

[1]

RECOVERIN - A POTENT UVEITOGEN FOR THE INDUCTION OF PHOTORECEPTOR DEGENERATION IN LEWIS RATS [J].

ADAMUS, G ;

ORTEGA, H ;

WITKOWSKA, D ;

POLANS, A .

EXPERIMENTAL EYE RESEARCH, 1994, 59 (04) :447-455

[2]

RECOVERIN - A CALCIUM SENSITIVE ACTIVATOR OF RETINAL ROD GUANYLATE-CYCLASE [J].

DIZHOOR, AM ;

RAY, S ;

KUMAR, S ;

NIEMI, G ;

SPENCER, M ;

BROLLEY, D ;

WALSH, KA ;

PHILIPOV, PP ;

HURLEY, JB ;

STRYER, L .

SCIENCE, 1991, 251 (4996) :915-918

[3]

GERY I, 1994, INVEST OPHTH VIS SCI, V35, P3342

[4]

Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer [J].

Güre, AO ;

Stockert, E ;

Scanlan, MJ ;

Keresztes, RS ;

Jäger, D ;

Altorki, NK ;

Old, LJ ;

Chen, YT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4198-4203

[5]

CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[6]

RECOVERIN, A PHOTORECEPTOR-SPECIFIC CALCIUM-BINDING PROTEIN, IS EXPRESSED BY THE TUMOR OF A PATIENT WITH CANCER-ASSOCIATED RETINOPATHY [J].

POLANS, AS ;

WITKOWSKA, D ;

HALEY, TL ;

AMUNDSON, D ;

BAIZER, L ;

ADAMUS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9176-9180

[7]

A PHOTORECEPTOR CALCIUM-BINDING PROTEIN IS RECOGNIZED BY AUTOANTIBODIES OBTAINED FROM PATIENTS WITH CANCER-ASSOCIATED RETINOPATHY [J].

POLANS, AS ;

BUCZYLKO, J ;

CRABB, J ;

PALCZEWSKI, K .

JOURNAL OF CELL BIOLOGY, 1991, 112 (05) :981-989

[8]

N-MYRISTOYLATION OF RECOVERIN ENHANCES ITS EFFICIENCY AS AN INHIBITOR OF RHODOPSIN KINASE [J].

SENIN, II ;

ZARGAROV, AA ;

ALEKSEEV, AM ;

GORODOVIKOVA, EN ;

LIPKIN, VM ;

PHILIPPOV, PP .

FEBS LETTERS, 1995, 376 (1-2) :87-90

[9]

Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: A possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction [J].

Senin, II ;

Dean, KR ;

Zargarov, AA ;

Akhtar, M ;

Philippov, PP .

BIOCHEMICAL JOURNAL, 1997, 321 :551-555

[10]

SMITT PAES, 1995, NEUROLOGY, V45, P1873