Reference interval determination for N-terminal-B-type natriuretic peptide (NT-proBNP): A study in blood donors

被引：56

作者：

Hess, G ^{[1
]}

Runkel, S

Zdunek, D

Hitzler, WE

机构：

[1] Roche Diagnost GMBH, Mannheim, Germany

[2] Johannes Gutenberg Univ Mainz Klinikum, Mainz, Germany

来源：

CLINICA CHIMICA ACTA | 2005年 / 360卷 / 1-2期

关键词：

N-terminal-pro-B-type natriuretic peptide (NT-proBNP); natriuretic peptides (NP); cardiac function; creatinine clearance; glomerular filtration rate (GFR); hemoglobin (Hb);

D O I：

10.1016/j.cccn.2005.04.031

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

We assessed reference values in a group of apparently healthy blood donors. A total of 1980 blood donors was recruited and tested for the presence of NT-proBNP using a newly developed electrochemiluminescence immunoassay (ECLIA) method. NT-proBNP clustered in all blood donors below the age of 50 years and an upper limit of normal (ULN) was found to be 84 pg/ml for males and 146 pg/ml for females. Mean NT-proBNP values increased with increasing age which was due to an increasing number of individuals exceeding the ULN. Age- and gender-appropriate NT-proBNP levels decreased with increasing hemoglobin levels. Hemoglobin but not creatinine levels influenced the NT-proBNP concentration in this cohort. The upper limit of normal can be used in clinical studies to further assess groups of diseased individuals to define clinical cutoffs. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：187 / 193

页数：7

共 21 条

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