Niacin and related compounds for treating hyperphosphatemia in dialysis patients

被引：18

作者：

Berns, Jeffrey S. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Hosp Univ Penn, Philadelphia, PA 19104 USA

来源：

SEMINARS IN DIALYSIS | 2008年 / 21卷 / 03期

关键词：

D O I：

10.1111/j.1525-139X.2008.00426.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Recent experimental and clinical studies suggest the possible utility of niacin (nicotinic acid, vitamin B3) and its metabolite nicotinamide as a means of lowering phosphate levels in dialysis patients via direct inhibition of the Na-Pi-2b sodium-dependent phosphate co-transporter in the GI tract. While the possibility of taking just one or two pills a day, which do not have to be taken with meals, is very attractive, caution is warranted before moving forward with niacin and related compounds for lowering phosphate levels in dialysis patients until it is certain that they are effective, well tolerated, and safe for treatment of chronic hyperphosphatemia.

引用

页码：203 / 205

页数：3

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