Development of thermal nociception in rats

被引:55
作者
Falcon, M
Guendellman, D
Stolberg, A
Frenk, H
Urca, G
机构
[1] TEL AVIV UNIV, DEPT PSYCHOL, IL-69978 RAMAT AVIV, ISRAEL
[2] TEL AVIV UNIV, DEPT PHYSIOL & PHARMACOL, IL-69978 RAMAT AVIV, ISRAEL
基金
以色列科学基金会;
关键词
thermal nociception; hypersensitivity; rat; neonate; reflex responsiveness;
D O I
10.1016/0304-3959(96)03070-9
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
In the present study, we show that hypersensitivity to noxious thermal stimulation can be seen clearly in developing rats. Rats, at postnatal days 3, 6, 9, 12, 15, 21 and 90 were tested for reflex responsiveness to noxious heat, using tail withdrawal from hot water as the assay. Thermal nociceptive thresholds are considerably lowered, relative to adults, up to postnatal day 12. Thresholds were 39, 37.5, 40.8, 43.3, 46.5, 45.2 and 47.2 degrees C for the respective age groups. Enhanced sensitivity to suprathreshold noxious stimuli is seen in neonates up to postnatal day 15 (but not on day 9). Starting on day 21, sensitivity to noxious stimuli decreases with increasing age, as can be seen by the decrease in the slope of the temperature-response curve (system gain). Spinal transections at postnatal days 13, 17, 20, 60, or 100 did not produce a change in nociceptive thresholds in any of the age groups. In contrast, sensitivity to noxious stimulation (system gain) was enhanced by spinalization in rats 20 days of age or older. Based on these results we suggest that threshold elevation with increasing age most probably reflects changes in local spinal properties, while changes in responsiveness to suprathreshold noxious stimuli involves maturation of both spinal and descending supraspinal structures.
引用
收藏
页码:203 / 208
页数:6
相关论文
共 18 条
[1]   THE CUTANEOUS WITHDRAWAL REFLEX IN HUMAN NEONATES - SENSITIZATION, RECEPTIVE-FIELDS, AND THE EFFECTS OF CONTRALATERAL STIMULATION [J].
ANDREWS, K ;
FITZGERALD, M .
PAIN, 1994, 56 (01) :95-101
[2]   A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].
BENNETT, GJ ;
XIE, YK .
PAIN, 1988, 33 (01) :87-107
[3]   THE POSTNATAL PHYSIOLOGICAL AND NEUROCHEMICAL DEVELOPMENT OF PERIPHERAL SENSORY C-FIBERS [J].
FITZGERALD, M ;
GIBSON, S .
NEUROSCIENCE, 1984, 13 (03) :933-+
[4]  
FITZGERALD M, 1988, DEV MED CHILD NEUROL, V30, P520
[5]   THE FUNCTIONAL-DEVELOPMENT OF DESCENDING INHIBITORY PATHWAYS IN THE DORSOLATERAL FUNICULUS OF THE NEWBORN RAT SPINAL-CORD [J].
FITZGERALD, M ;
KOLTZENBURG, M .
DEVELOPMENTAL BRAIN RESEARCH, 1986, 24 (1-2) :261-270
[6]  
FITZGERALD M, 1985, J PHYSIOL-LONDON, V364, P1
[7]  
FITZGERALD M, 1994, TXB PAIN, P153
[8]   IS SUBSTANCE-P A PRIMARY AFFERENT NEUROTRANSMITTER FOR NOCICEPTIVE INPUT .1. ANALYSIS OF PAIN-RELATED BEHAVIORS RESULTING FROM INTRATHECAL ADMINISTRATION OF SUBSTANCE-P AND 6 EXCITATORY COMPOUNDS [J].
FRENK, H ;
BOSSUT, D ;
URCA, G ;
MAYER, DJ .
BRAIN RESEARCH, 1988, 455 (02) :223-231
[9]   DEVELOPMENTAL ALTERATIONS IN NOCICEPTIVE THRESHOLD, IMMUNOREACTIVE CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P, AND FLUORIDE-RESISTANT ACID-PHOSPHATASE IN NEONATALLY CAPSAICIN-TREATED RATS [J].
HAMMOND, DL ;
RUDA, MA .
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 312 (03) :436-450
[10]   PAIN IN INFANCY - CONCEPTUAL AND METHODOLOGICAL ISSUES [J].
OWENS, ME .
PAIN, 1984, 20 (03) :213-230