Labeling of rat neurons by anti-GluR3 IgG from patients with Rasmussen encephalitis

被引：20

作者：

Frassoni, C

Spreafico, R

Franceschetti, S

Aurisano, N

Bernasconi, P

Garbelli, R

Antozzi, C

Taverna, S

Granata, T

Mantegazza, R

机构：

[1] Ist Nazl Neurol Carlo Besta, Dept Expt Neurophysiol & Epileptol, I-20133 Milan, Italy

[2] Ist Nazl Neurol Carlo Besta, Myopathol & Immunol Unit, I-20133 Milan, Italy

[3] Ist Nazl Neurol Carlo Besta, Dept Neuromuscular Dis, I-20133 Milan, Italy

[4] Ist Nazl Neurol Carlo Besta, Dept Child Neurol, I-20133 Milan, Italy

来源：

NEUROLOGY | 2001年 / 57卷 / 02期

关键词：

D O I：

10.1212/WNL.57.2.324

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report the immunocytochemical localization in rat brain of affinity-purified anti-GluR3 (glutamate receptor) antibodies from two patients with Rasmussen encephalitis (RE) and from immunized rabbits, The distribution of immunolabeling was similar using antibodies from rabbits and patients with RE. No electrophysiologic responses were elicited from acutely dissociated kainate-responsive neurons isolated from rat brain when these antibodies were applied. These findings show that anti-GluR3 antibodies purified from patients with RE bind to specific regions of the CNS but do not act through an excitotoxic mechanism.

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页码：324 / 327

页数：4

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