The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene

被引：13

作者：

McKinnon, PJ ^{[1
]}

Kapsetaki, M ^{[1
]}

Margolskee, RF ^{[1
]}

机构：

[1] MT SINAI MED CTR, DEPT PHYSIOL & BIOPHYS, NEW YORK, NY 10029 USA

来源：

GENOME RESEARCH | 1996年 / 6卷 / 11期

关键词：

D O I：

10.1101/gr.6.11.1077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scl and Spare are two extracellular proteins sharing similarity in their carboxyl terminus, with 63% identity over a 232-amino-acid region. We have cloned and mapped the genomic locus of mouse Set The mouse Sd gene contains 11 exons spanning similar to 35 kb of DNA. The genomic structure (exon/intron boundaries) of Sd exons 6 to exon 11 is identical to those of the similar portion of the Spare gene. This suggests that Sd and Spare originated from a common ancestral gene. Using fluorescence in situ hybridization analysis, Sd was localized to band 5E4 of mouse chromosome 5.

引用

页码：1077 / 1083

页数：7

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