A review of recent, unconventional applications of ion mobility spectrometry (IMS)

被引：228

作者：

Armenta, Sergio ^{[1
]}

Alcala, Manel ^{[1
]}

Blanco, Marcelo ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Fac Sci, Dept Chem, E-08193 Barcelona, Spain

来源：

ANALYTICA CHIMICA ACTA | 2011年 / 703卷 / 02期

关键词：

Ion mobility spectrometry; Pharmaceuticals; Food analysis; Environmental analysis; Clinical analysis; Process control; SOLID-PHASE MICROEXTRACTION; VOLATILE ORGANIC-COMPOUNDS; TERT-BUTYL ETHER; MASS-SPECTROMETRY; POLYPYRROLE FILM; HUMAN SERUM; IONIZATION SOURCE; LASER-DESORPTION/IONIZATION; RESOLVING POWER; EXHALED BREATH;

D O I：

10.1016/j.aca.2011.07.021

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The applications of ion mobility spectrometry (IMS) have grown exponentially beyond its uses for explosive, illicit drug and chemical warfare agent monitoring in recent years. Instrumental developments including new drift tube materials and ionization sources have enabled the manufacturing of more sophisticated and affordable IMS equipment for the advantageous analysis of samples with no pretreatment. The most recent applications of IMS include quality control and cleaning validation procedures in the pharmaceutical industry; determinations of contaminants in food samples; clinical analyses of biological fluids; environmental analyses of contaminants in gaseous, liquid and solid samples; and (bio)process quality control monitoring. Coupling IMS with MSn has enabled the analysis of very complex samples and the extraction of knowledge unavailable from isolated MS measurements, especially in the polymer and petroleomic industries. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：114 / 123

页数：10

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