Poised RNA polymerase II gives pause for thought

被引：116

作者：

Margaritis, Thanasis ^{[1
]}

Holstege, Frank C. P. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Physiol Chem, NL-3584 CG Utrecht, Netherlands

来源：

CELL | 2008年 / 133卷 / 04期

关键词：

D O I：

10.1016/j.cell.2008.04.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

引用

页码：581 / 584

页数：4

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