The AMP-activated protein kinase cascade - a unifying system for energy control

被引：925

作者：

Carling, D ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci,Cellular Stress Grp, London W12 0NN, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tibs.2003.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that acts as an intracellular energy sensor maintaining the energy balance within the cell. This pivotal role of AMPK places it in an ideal position for regulating whole-body energy metabolism, and AMPK might play a part in protecting the body from metabolic diseases such as type 2 diabetes and obesity. Mutations in AMPK cause cardiac hypertrophy and arrhythmia. Recent findings have identified LKB1 - a protein kinase that is mutated in a hereditary form of cancer - as a candidate for the upstream kinase in the AMPK cascade. AMPK could provide a link in human diseases of which the underlying cause is due to defects in energy metabolism.

引用

收藏

页码：18 / 24

页数：7

相关论文

共 62 条

[1] Leptin [J].

Ahima, RS ;

Flier, JS .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437

[2]

Andersson L, 2003, BIOCHEM SOC T, V31, P232, DOI 10.1042/BST0310232

[3] Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy [J].

Arad, M ;

Moskowitz, IP ;

Patel, VV ;

Ahmad, F ;

Perez-Atayde, AR ;

Sawyer, DB ;

Walter, M ;

Li, GH ;

Burgon, PG ;

Maguire, CT ;

Stapleton, D ;

Schmitt, JP ;

Guo, XX ;

Pizard, A ;

Kupershmidt, S ;

Roden, DM ;

Berul, CI ;

Seidman, CE ;

Seidman, JG .

CIRCULATION, 2003, 107 (22) :2850-2856

[4] Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy [J].

Arad, M ;

Benson, DW ;

Perez-Atayde, AR ;

McKenna, WJ ;

Sparks, EA ;

Kanter, RJ ;

McGarry, K ;

Seidman, JG ;

Seidman, CE .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (03) :357-362

[5] The structure of a domain common to archaebacteria and the homocystinuria disease protein [J].

Bateman, A .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) :12-13

[6] Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides [J].

Beauloye, C ;

Marsin, AS ;

Bertrand, L ;

Krause, U ;

Hardie, DG ;

Vanoverschelde, JL ;

Hue, L .

FEBS LETTERS, 2001, 505 (03) :348-352

[7] Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis [J].

Blair, E ;

Redwood, C ;

Ashrafian, H ;

Oliveira, M ;

Broxholme, J ;

Kerr, B ;

Salmon, A ;

Östman-Smith, I ;

Watkins, H .

HUMAN MOLECULAR GENETICS, 2001, 10 (11) :1215-1220

[8] THE SUBSTRATE AND SEQUENCE SPECIFICITY OF THE AMP-ACTIVATED PROTEIN-KINASE - PHOSPHORYLATION OF GLYCOGEN-SYNTHASE AND PHOSPHORYLASE-KINASE [J].

CARLING, D ;

HARDIE, DG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1012 (01) :81-86

[9]

CARLING D, 1994, J BIOL CHEM, V269, P11442

[10] Glucose repression in yeast [J].

Carlson, M .

CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (02) :202-207

← 1 2 3 4 5 6 7 →