Airway transplantation: A debate worth having?

被引:29
作者
Birchall, Martin [1 ]
Macchiarini, Paolo [2 ]
机构
[1] Univ Bristol, Laryngeal Res Grp, Bristol BS40 5DU, Avon, England
[2] Univ Barcelona, Dept Gen Thorac Surg, Hosp Clin, Fdn Clin,IDIBAPS, Barcelona, Spain
关键词
laryngeal transplantation; tracheal transplantation; tissue engineering; reinnervation; mucosal immunity;
D O I
10.1097/TP.0b013e31816a10e4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Laryngeal and tracheal transplantation have been proposed as treatments for irreversible airway disease for many years. Despite much research, there has only been one true laryngeal transplant reported. Although this was in many ways a success, several barriers remain before full clinical trials. There are issues over patient selection, reinnervation, immunosuppression, and cost-benefit. For the trachea, where finely tuned neuromuscular activity is not an issue, tissue-engineering probably represents the future. This overview discusses the arguments for and against laryngeal and tracheal transplantation and suggests ways of overcoming these barriers.
引用
收藏
页码:1075 / 1080
页数:6
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