Sickle red cell adhesion: Many issues and some answers

被引：13

作者：

Kaul, D. K. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

来源：

TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2008年 / 15卷 / 1-2期

关键词：

sickle red cell deformability; adhesion; vaso-occlusion; endothelium; adhesion molecules;

D O I：

10.1016/j.tracli.2008.03.012

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Among multiple pathologies associated with sickle cell disease, sickle red cell-endothelial interaction has been implicated as a potential initiating mechanism in vaso-occlusive events that characterize this disease. Vast literature exists on various aspects of sickle red cell adhesion, but many issues remain unresolved, especially pertaining to the role of sickle red cell heterogeneity, the relative role of multiple adhesion mechanisms and targets of antiadhesive therapy. This review briefly analyzes these issues. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：51 / 55

页数：5

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