GTPases in antigen receptor signalling

被引：62

作者：

Henning, SW ^{[1
]}

Cantrell, DA ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Lymphocyte Activat Lab, London WC2A 3PX, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(98)80171-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological interest in small GTPases has focused for some years almost exclusively on the role of Ras in promoting lymphocyte activation and development. A new concept in this field is that GTPases are linked to multiple biochemical effector signalling pathways and are consequently able to regulate diverse cellular processes. It is also now recognised that GTPases other than Ras regulate lymphocyte biology. Rap1 has been suggested as a negative regulator of lymphocyte responses and Rho GTPases are important components of signalling pathways used by antigen receptors and by costimulatory, cytokine and chemokine receptors to regulate the immune response.

引用

页码：322 / 329

页数：8

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