Effects of prolactin-releasing peptide (PrRP) on sleep regulation in rats

被引：21

作者：

Zhang, SQ ^{[1
]}

Kimura, M ^{[1
]}

Inoué, S ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Biocybernet, Div Biosyst,Chiyoda Ku, Tokyo 1010062, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2000年 / 54卷 / 03期

关键词：

pituitary; prolactin (PRL); prolactin-releasing peptide (PrRP); rat; sleep;

D O I：

10.1046/j.1440-1819.2000.00670.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present study examined in rats how prolactin-releasing peptide (PrRP), a new hypothalamic hormone, infused centrally during the dark period affects sleep and plasma levels of prolactin (PRL). At a dose of 0.1 nmol, PrRP increased only rapid eye movement (REM) sleep, whereas with 1.0 nmol both non-REM sleep and REM sleep were enhanced. However, 10.0 nmol of PrRP increased only non-REM: sleep with a febrile response. The levels of plasma PRL were elevated during the infusion of PrRP with 0.1 and 1.0 nmol. Consequently, the increased release of PRL correlated with significant increases in REM sleep, but not in non-REM sleep.

引用

页码：262 / 264

页数：3

共 5 条

[1] A prolactin-releasing peptide in the brain [J].