Prazosin Treatment of Trauma Nightmares and Sleep Disturbance in Soldiers Deployed in Iraq

被引：26

作者：

Calohan, Jess

Peterson, Kris

Peskind, Elaine R.

Raskind, Murray A.

机构：

[1] Madigan Army Medical Center and VA Northwest Network Mental Illness, Research Education and Clinical Center

来源：

JOURNAL OF TRAUMATIC STRESS | 2010年 / 23卷 / 05期

关键词：

COMBAT VETERANS; SYMPTOMS;

D O I：

10.1002/jts.20570

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Trauma nightmares and sleep disturbance impair combat soldiers' functioning. The alpha-1 adrenoreceptor antagonist prazosin has been demonstrated effective for these symptoms in Vietnam veterans. Thirteen soldiers seeking relief from distressing trauma nightmares impairing military function in northern Iraq in 2006 received prazosin alone or in combination with other psychotropics. Mean prazosin dose was 4.1 (SD = 2.2) mg before bed. Six soldiers improved markedly and 3 moderately on the Clinical Global Impression of Change Ratings of distressing dreams decreased from an average of 7.0 (SD = 0.7) to 2.9 (SD = 3.0, p < .001) and those of disturbed sleep from 67 (SD = 0.9) to 3.7 (SD = 2.4, p < .001). Prazosin appears effective and well tolerated in the desert warfare environment.

引用

页码：645 / 648

页数：4

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