Inactivating chromosomes:: A macro domain that minimizes transcription

被引：73

作者：

Ladurner, AG

机构：

[1] European Mol Biol Lab, Gene Express Programme, D-69117 Heidelberg, Germany

[2] European Mol Biol Lab, Struct & Computat Biol Programme, D-69117 Heidelberg, Germany

来源：

MOLECULAR CELL | 2003年 / 12卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(03)00284-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.

引用

页码：1 / 3

页数：3

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