Circling behaviour in 6-hydroxydopamine-lesioned rats given pulsed levodopa is reduced more by lesions in the entopeduncular nucleus substantia nigra pars reticulata than in the subthalamic nucleus

被引：14

作者：

Honey, CR ^{[1
]}

Shen, H ^{[1
]}

机构：

[1] Univ British Columbia, Div Neurosurg, Vancouver, BC V6T 1Z3, Canada

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

rodent; 6-hydroxydopamine; levodopa; subthalamic nucleus; entopeduncular nucleus; substantia nigra pars reticulata; circling behaviour; apomorphine;

D O I：

10.1016/S0304-3940(98)00431-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats unilaterally lesioned with 6-hydroxydopamine to deplete striatal dopamine received daily injections of levodopa methyl ester in combination with benserazide. Delayed lesions in the subthalamic nucleus (Group 2) or entopeduncular nucleus and substantia nigra par reticulata (Group 3) were made, unilateral to the dopamine depletion. Apomorphine-induced rotation was significantly reduced in Group 2 versus sham-operated controls (P < 0.006) and in Group 3 versus Group 2 (P < 0.03). Results suggest that enhanced apomorphine-induced rotation in this model is mediated through both the striatopallidal and striatonigral pathway. (C) 1998 Published by Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：151 / 154

页数：4

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